Our team is interested in understanding alterations in the levels of neuromodulators such as dopamine, serotonin or norepinephrine in the brain. Changed levels of neuromodulation are linked not only to many psychiatric disorders, but also influence everyday cognitive performance: Fatigue, excitement and sadness e.g. are all correlated to activity patterns of neurons releasing such neuromodulators. While specific behaviors have been linked to specific neuromodulators, and while activation of certain receptors and their downstream signalling pathways have been associated with these neuromodulators, it still remains largely unknown how neuromodulatory neurons themselves function, how they adapt and how their global projections still allow for area-specificity.

These are complex questions involving numerous different brain structures. We are currently tackling them on various complexity levels: From molecules to neuronal circuits in cell culture all the way up to behaving mice. By combining designer photoreceptors with viral delivery strategies, we can control neuronal activity with light. Our working hypothesis is that these neuromodulatory systems form an overarching structure within local neuronal circuits and concert activity in various brain regions. How these neuromodulatory networks integrate information and how they adapt to environmental stressors or age are key questions of our research.

#TBT in situ cryo-electron tomogram of the native Chlamydomonas Golgi

Tomographic volume superimposed with the 3D segmentation.

Published in @eLife by the @BriggsGroup, established @EMBL in 2006 before moving to @MRC_LMB in 2017.

📹 https://t.co/awZaIJXcTo
#throwbackthursday

We have three #PhD positions available as part of an exciting translational project with @d_haemmerer @_MaPr_ + Tino Zaehle to study how tVNS can stimulate the noradrenergic system in ageing! For more info contact us! Please RT https://t.co/autUWare2Y @ResearchGermany #PhDGermany

Yeah - can we stimulate the Locus coeruleus non-invasively with tVNS? 👂⚡️Dont know - but we ll figure it out - in a fun(ny) team across species here at #OvGU #LIN in Magdeburg - 3PhD positions! @MTJBetts @d_haemmerer

@MTJBetts @grinberg_t @_MaPr_ ...and there is a parallel project with LC stim in rodents with @_MaPr_ to look at the time course of stimulation effects on the LC-NA system!!! Stoked.

Plans underway for the 2nd LC imaging meeting. Excited to confirm it will be on the 12-13th of Dec at the @DZNE_en Magdeburg. Please contact myself or @d_haemmerer if you wish to join. Shaping up to be a cracking lineup! More details to follow... #locuscoeruleus

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