Our team is interested in understanding alterations in the levels of neuromodulators such as dopamine, serotonin or norepinephrine in the brain. Changed levels of neuromodulation are linked not only to many psychiatric disorders, but also influence everyday cognitive performance: Fatigue, excitement and sadness e.g. are all correlated to activity patterns of neurons releasing such neuromodulators. While specific behaviors have been linked to specific neuromodulators, and while activation of certain receptors and their downstream signalling pathways have been associated with these neuromodulators, it still remains largely unknown how neuromodulatory neurons themselves function, how they adapt and how their global projections still allow for area-specificity.

These are complex questions involving numerous different brain structures. We are currently tackling them on various complexity levels: From molecules to neuronal circuits in cell culture all the way up to behaving mice. By combining designer photoreceptors with viral delivery strategies, we can control neuronal activity with light. Our working hypothesis is that these neuromodulatory systems form an overarching structure within local neuronal circuits and concert activity in various brain regions. How these neuromodulatory networks integrate information and how they adapt to environmental stressors or age are key questions of our research.

Great talk on how a defined population of PV neurons syncs septo-hippocampal theta-oscillation by @balazs_hangya in our new onLIN_e seminar series 🔥🔥 here @LIN_Magdeburg. Thanks to Balazs and @SMikulovic

https://t.co/3DSWgLK6QK @_MaPr_
Stephane Lehericy (France)
Matthias Prigge (Germany)
Matthew Betts (Germany)
Congrats to everyone and let´s do this together💪

Lust am LIN zu arbeiten❓
Im Bereich des #Labormanagements vergibt das LIN zum nächstmöglichen Zeitpunkt eine Stelle in Vollzeit als Technische*r Assistent*in.
➡️ https://t.co/3ydd2T8S0l

Stoked! that our latest work is out @NeuroCellPress: a large viral toolbox for intersectional expression of molecular tools in cells defined by multiple parameters. https://t.co/WUhJHhpARV 1/5

Happy to see this work finally published - was waiting for it ... Well done - @Sergey84946655 & YairShemesh in @alon_chen_lab + @ShlomoWagner @OferYizhar - are there commercial plans ahead?

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